ea0025oc2.8 | Steroids | SFEBES2011
Stimson Roland
, Andrew Ruth
, Jones Gregory
, Livingstone Dawn
, Smith Kenneth
, Walker Brian
Inhibiting cortisol regeneration by 11β-HSD1 is a promising therapy for type two diabetes. In obesity, 11β-HSD1 activity is increased in adipose tissue but decreased in the liver, the latter putatively mediated by hyperinsulinaemia. We tested whether insulin sensitisation with metformin regulates 11β-HSD1 activity in whole body and in liver in obesity.Five obese men (age 48±5 years, BMI 39.8±3.6 kg/m2) participated in ...